hrp0092p2-16 | Adrenals and HPA Axis | ESPE2019

A Case of Infantile Cushing's Syndrome from McCune Albright Syndrome: The Importance of Multiple-Site Sampling for Genetic Testing

Beng Hui Ng Nicholas , Tay Vanerry LQ , Ooi Delicia SQ , Loke Kah Yin

Case Description: We report a case of a 7-month old Vietnamese boy who presented with failure to thrive and a Cushingoid appearance from 1 month old. There was no history of exogenous steroid use. On examination, height and weight were <3rd centile. He was Cushingoid with motor development delay. There were multiple large café-au-lait lesions over the sacral region but no limb asymmetry to suggest fibrous dysplasia.En...

hrp0097p1-55 | Fat, Metabolism and Obesity | ESPE2023

Association between serum uric acid and blood pressure in children and adolescents: A systematic review-meta regression

Beng Hui Ng Nicholas , Han Luke , Tan Rachel , Ven Yap Qai , Huak Chan Yiong

Background: Hyperuricaemia has been associated with increased risk of metabolic syndrome in adults and children. Elevation in serum uric acid (SUA) is hypothesized to be a critical initiator of the development of essential hypertension. The exact relationship between SUA and blood pressure (BP) has not been established in the pediatric population. We conducted a systematic review to evaluate the association between SUA and BP in well, obese/overweight and hype...

hrp0092p1-44 | Fat, Metabolism and Obesity | ESPE2019

Metabolic Complications After Paediatric Liver Transplantation: A 10-year Longitudinal Study in a South-East Asian Population

Beng Hui Ng Nicholas , Yijuan Lim Yvonne , Wei Li Ho Cindy , Anjian Sng Andrew , Aw Marion , Seng Lee Yung , Yin Loke Kah

Background: Improved patient and graft survival post-liver transplantation has led to a parallel increase in metabolic syndrome (MS) reported in multiple centres. We aimed to study the prevalence and risk factors of metabolic complications in our paediatric liver transplant (LT) cohort.Methods: This was a retrospective review of the LT database from 1995-2018. We studied the incidence of overweight, obesity (WHO BMI crit...

hrp0097p1-151 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Clinical profile of children with central precocious puberty in a single tertiary centre

Yen Wee Chun , Beng Hui Ng Nicholas , Wei Li Ho Cindy , Anjian Sng Andrew , Leiqiu Tay Vanerry , Seng Lee Yung , Yin Loke Kah , Yijuan Lim Yvonne

Introduction: Our study aimed to describe the clinical profile of children with central precocious puberty (CPP) presenting to a single tertiary centre, and to determine the factors that would lead patients and families to pursue treatment with gonadotrophin releasing hormone (GnRH) agonist as well as the predictors of a more favourable final adult height in this cohort.Methods: We conducted a retrospective medical chart...